产品详情
  • 产品名称:PeptidylprolylIsomeraseA(CyclophilinA)(PPIA)Protein

  • 产品型号:
  • 产品厂商:DIATHEVA
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简单介绍:
PeptidylprolylIsomeraseA(CyclophilinA)(PPIA)Protein
详情介绍:
Purity >99 %
Background Cyclophilin A (CypA, 18 kDa) is the first peptidyl-prolil cis-trans isomerase (PPIase) to be discovered, PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilins belong to the superfamily of immunophilins, highly conserved cytoplasmic proteins which share the PPI enzymatic activity and the ability to bind immunosuppressive drugs. CypA binds to and mediates the effect of Cyclosporin A, the CsA/CypA complex selectively binds and inactivates the serine/theronine phosphatase calcineurin leading to disruption of T-cells activating cascade. CsA binding occurs at the active site of the protein thus inhibiting its enzymatic activity. CypA has been demonstrated to be involved in several steps of viral infections such as those mediated by HIV, HBV and HCV.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 20 mM Tris pH 8.0, 20 mM NaCl, 0.5 mM DTT, 10 % (v/v) glycerol
Storage -20 °C