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  • 产品名称：LaminA/C(LMNA)Protein

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  • 产品厂商：DIATHEVA
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简单介绍：
LaminA/C(LMNA)Protein
详情介绍：
Characteristics Recombinant human lamin A is a 645 amino acids protein with a molecular weight of 70 kDa.
Purity > 90 %
Background Lamin A is a major component of the nuclear lamina, a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene (LMNA). Lamin A is synthesized as a longer precursor, prelamin A (code REP0038), that in vivo undergoes to serial post-translational modifications that lead to mature lamin A. Different mutations in the LMNA gene have been associated with different diseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familiar partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Pathways Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 20 mM phosphate buffer pH 7.0, 0.5M NaCl, 1 mM DTT, 1.5 mM EDTA, 20 % (v/v) glycerol
Storage -20 °C