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Alternative Name
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TRAF2 (TRAF2 Antibody Abstract)
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Background
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TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses. Members of the TRAF family share a common carboxy-terminal TRAF domain" which mediates interactions with associated proteins, many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2 (TNFRII). The six known TRAFs (TRAF1-6) act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation it has since been shown to interact with other surface receptors including CD27, CD30, CD40 , TRAF1 and TRAF2 and stress responses.While TRAF2 was originally described through its interaction with TNFRII
Synonyms: 4-1BB
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Research Area
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Cardiovascular, Atherosclerosis, Growth Factors, Apoptosis/Necrosis
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Pathways
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NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded protein response
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