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  • 产品名称：Interleukin21(IL21)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Interleukin21(IL21)(Active)Protein
详情介绍：
Sequence HKSSPQGPDR LLIRLRHLID IVEQLKIYEN DLDPELLSAP QDVKGHCEHA AFACFQKAKL KPSNPGNNKT FIIDLVAQLR RRLPARRGGK KQKHIAKCPS CDSYEKRTPK EFLERLKWLL QKMIHQHLS
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/mL, corresponding to a specific activity of ＞ 4.0 x 104 IU/mg.
Purity >98 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11970879, ECO:0000269|PubMed:12893770, ECO:0000269|PubMed:15100251}.
Synonyms: IL-21,
Molecular Weight 15.0 kDa
UniProt Q9ES17
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Restrictions For Research Use only
Format Lyophilized
Buffer 2 x PBS, pH 7.4
Storage -20 °C