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  • 产品名称：Noggin(NOG)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Noggin(NOG)(Active)Protein
详情介绍：
Sequence MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/mL, corresponding to a specific activity of ＞ 3.3 x 105 IU/mg in the presenc
Purity >95 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273}.
Molecular Weight 46.3 kDa
UniProt Q13253
Pathways Stem Cell Maintenance, Tube Formation
Restrictions For Research Use only
Format Lyophilized
Buffer 30 % acetonitrile, 0.1 % TFA
Storage -20 °C