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  • 产品名称：TumorNecrosisFactorReceptorSuperfamily,Member1A(TNFRSF1A)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
TumorNecrosisFactorReceptorSuperfamily,Member1A(TNFRSF1A)(Active)Protein
详情介绍：
Sequence IYPSGVIGLV PHLGDREKRD SVCPQGKYIH PQNNSICCTK CHKGTYLYND CPGPGQDTDC RECESGSFTA SENHLRHCLS CSKCRKEMGQ VEISSCTVDR DTVCGCRKNQ YRHYWSENLF QCFNCSLCLN GTVHLSCQEK QNTVCTCHAG FFLRENECVS CSNCKKSLEC TKLCLPQIEN VKGTEDSGTT
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.05 μg/mL, corresponding to a specific activity of ＞ 2 x 104IU/mg in the presence of
Purity >97?% as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Synonyms: Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55
Molecular Weight 21.2 kDa
UniProt P19438
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C
Restrictions For Research Use only
Format Lyophilized
Buffer PBS,?pH 7.4
Storage -20 °C