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  • 产品名称：Chemokine(C-CMotif)Ligand4(CCL4)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Chemokine(C-CMotif)Ligand4(CCL4)(Active)Protein
详情介绍：
Sequence APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
Characteristics Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 5.0-20 ng/mL.
Purity >96 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.
Synonyms: G-26 T-lymphocyte-secreted protein, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta1-69,
Molecular Weight 7.8 kDa
UniProt P13236
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4
Storage -20 °C