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  • 产品名称：IndianHedgehog(IHH)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
IndianHedgehog(IHH)(Active)Protein
详情介绍：
Sequence IIGPGRVVGS RRRPPRKLVP LAYKQFSPNV PEKTLGASGR YEGKIARSSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDRLNSLAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRNKYGLL ARLAVEAGFD WVYYESKAHV HCSVKSEHSA AAKTGG
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by C3H10T1/2(CCL-226) cells is 3.0-10 μg/mL.
Purity >96 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). {ECO:0000250}.
Synonyms: IHH,
Molecular Weight 19.8 kDa
UniProt Q14623
Pathways Hedgehog Signaling
Restrictions For Research Use only
Format Lyophilized
Buffer 20 mM PB, pH 7.4, 150 mM NaCl
Storage -20 °C