产品详情
查看大图

  • 产品名称：Heparin-BindingEGF-LikeGrowthFactor(HBEGF)(Active)Protein

  • 产品型号：
  • 产品厂商：SXBIO
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Heparin-BindingEGF-LikeGrowthFactor(HBEGF)(Active)Protein
详情介绍：
Sequence DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/mL, corresponding to a specific activity of ＞ 1.0 x 106 IU/mg.
Purity >97 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Synonyms: HB-EGF, Diphtheria toxin receptor, DT-R,],
Molecular Weight 9.7 kDa
UniProt Q99075
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Restrictions For Research Use only
Format Lyophilized
Buffer 20 mM PB, pH 7.4, 130 mM NaCl
Storage -20 °C