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  • 产品名称：Interleukin11(IL11)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Interleukin11(IL11)(Active)Protein
详情介绍：
Sequence MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1 ng/mL, corresponding to a specific activity of ＞ 1.0 x 106 IU/mg.
Purity >95?% as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}.
Synonyms: IL-11, AGIF, Oprelvekin
Molecular Weight 19.1 kDa
UniProt P20809
Research Area Stem Cells, Hematopoietic Progenitors, Cytokines, Innate Immunity, Adaptive Immunity, Angiogenesis
Pathways JAK-STAT Signaling, Negative Regulation of Hormone Secretion
Restrictions For Research Use only
Format Lyophilized
Buffer PBS,?pH 7.4
Storage -20 °C