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  • 产品名称：TumorNecrosisFactor(Ligand)Superfamily,Member13b(TNFSF13B)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
TumorNecrosisFactor(Ligand)Superfamily,Member13b(TNFSF13B)(Active)Protein
详情介绍：
Sequence MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a mouse splenocyte survival assay is 0.5-2 μg/mL.
Purity >95 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}., Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000250}., Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.
Synonyms: B lymphocyte stimulator, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1
Molecular Weight 17.2 kDa
UniProt Q9Y275
Research Area Cell Cycle, Cancer
Pathways NF-kappaB Signaling, Production of Molecular Mediator of Immune Response
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4, with 0.02 % Tween-20
Storage -20 °C