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  • 产品名称：FibroblastGrowthFactor19(FGF19)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
FibroblastGrowthFactor19(FGF19)(Active)Protein
详情介绍：
Sequence MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150 ng/mL, corresponding to a specific activity of ＞ 6.7 x 103 IU/mg.
Purity >95 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:19085950}.
Synonyms: FGF-19,
Molecular Weight 21.8 kDa
UniProt O95750
Research Area Cancer, Growth Factors, Wnt
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4
Storage -20 °C