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  • 产品名称：anti-ImmunodeficiencyVirusType2ProteinVpx(AA1-113),(subtypeA)antibody

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  • 产品厂商：SXBIO
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简单介绍：
anti-ImmunodeficiencyVirusType2ProteinVpx(AA1-113),(subtypeA)antibody
详情介绍：
Immunogen Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein(1-113AA)
Isotype IgG
Purification Caprylic Acid Ammonium Sulfate Precipitation purified
Background Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
UniProt P18099
Restrictions For Research Use only
Format Liquid
Buffer Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C/-80 °C