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  • 产品名称：Pleiotrophin(PTN)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Pleiotrophin(PTN)(Active)Protein
详情介绍：
Sequence GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
Characteristics Biological Activity: Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been pre-coated wi
Purity >96 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.
Synonyms: PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule
Molecular Weight 15.3 kDa
UniProt P21246
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4
Storage -20 °C