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Alternative Name
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beta-Adrenergic Receptor Kinase 1 (ADRBK1 Antibody Abstract)
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Background
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Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Synonyms: G-protein coupled receptor kinase 2,ADRBK1,BARK, BARK1, GRK2
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UniProt
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P25098
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Pathways
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EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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