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Background
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Probable component of the SCF E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
Synonyms: RING finger protein 7 Regulator of cullins 2 Sensitive to apoptosis gene protein RNF7,RBX2, ROC2, SAG
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