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  • 产品名称：anti-ALKBH8antibody(AlkB,AlkylationRepairHomolog8(E.Coli))(AA1-230)

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  • 产品厂商：SXBIO
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简单介绍：
anti-ALKBH8antibody(AlkB,AlkylationRepairHomolog8(E.Coli))(AA1-230)
详情介绍：
Immunogen Recombinant humanAlkylated DNA repair protein alkB homolog 8 protein (1-230aa)
Isotype IgG
Purification Antigen Affinity purified
Alternative Name Alkylated DNA Repair Protein AlkB Homolog 8 (ALKBH8 Antibody Abstract)
Background Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine, has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).
UniProt Q96BT7
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C/-80 °C