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  • 产品名称：anti-LDLRAP1antibody(LowDensityLipoproteinReceptorAdaptorProtein1)(AA59-308)

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  • 产品厂商：SXBIO
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简单介绍：
anti-LDLRAP1antibody(LowDensityLipoproteinReceptorAdaptorProtein1)(AA59-308)
详情介绍：
Immunogen Recombinant human Low density lipoprotein receptor adapter protein 1 protein (59-308aa)
Isotype IgG
Purification Antigen Affinity Purified
Alternative Name Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1 Antibody Abstract)
Background Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
UniProt Q5SW96
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C/-80 °C