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  • 产品名称：anti-Glutaredoxin2antibody(GRX2)(AA1-124)

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  • 产品厂商：SXBIO
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简单介绍：
anti-Glutaredoxin2antibody(GRX2)(AA1-124)
详情介绍：
Immunogen Recombinant human Glutaredoxin-2, mitochondrial protein (1-124aa)
Isotype IgG
Purification Antigen Affinity Purified
Alternative Name Glutaredoxin-2, Mitochondrial (GRX2 Antibody Abstract)
Background Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
UniProt Q9NS18
Pathways Cell RedoxHomeostasis
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C/-80 °C