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  • 产品名称：anti-TRADDantibody(TNFRSF1A-AssociatedViaDeathDomain)(AA1-312)

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  • 产品厂商：SXBIO
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简单介绍：
anti-TRADDantibody(TNFRSF1A-AssociatedViaDeathDomain)(AA1-312)
详情介绍：
Immunogen Recombinant human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312aa)
Isotype IgG
Purification Antigen Affinity Purified
Alternative Name Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD Antibody Abstract)
Background The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
UniProt Q15628
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C/-80 °C