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  • 产品名称：DickkopfHomolog1(XenopusLaevis)(DKK1)(AA32-266)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
DickkopfHomolog1(XenopusLaevis)(DKK1)(AA32-266)(Active)Protein
详情介绍：
Sequence Thr32 - His266, Accession # O94907
Characteristics Biological Activity: The ED50, as determined by inhibition of Wnt-3a induced alkaline phosphatase production using mouse MC3T3E1 cells, is less than 150 ng/mL.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.2 μm filtered
Background Relevance: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Synonyms: Dickkopf-1, hDkk-1, SK
Molecular Weight 25.8 kDa
UniProt O94907
Research Area Embryogenesis, Wnt
Pathways WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Restrictions For Research Use only
Format Lyophilized
Buffer 20 mM PB, pH 7.4, 150 mM NaCl
Storage -20 °C