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  • 产品名称：anti-ZBTB33antibody(ZincFingerandBTBDomainContaining33)(AA564-674)

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简单介绍：
anti-ZBTB33antibody(ZincFingerandBTBDomainContaining33)(AA564-674)
详情介绍：
Immunogen ZBTB33 (AAH42753, 564 a.a. ~ 674 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B2
Isotype IgG2a kappa
Specificity ZBTB33 (AAH42753, 564 a.a. ~ 674 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name ZBTB33 (ZBTB33 Antibody Abstract)
Background This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO- TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α,2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Synonyms: ZNFkaiso, ZNF348 zinc finger and BTB domain containing 33
Molecular Weight 74484 DA
Gene ID 10009
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO- TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α,2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Zinc Finger and BTB Domain Containing 33 (ZBTB33) (AA 564-674) antibody (ABIN393564) Western Blot analysis of ZBTB33 expression in transfected 293T cell line by ZBTB33 mo...
Immunohistochemistry (IHC) image for anti-Zinc Finger and BTB Domain Containing 33 (ZBTB33) (AA 564-674) antibody (ABIN393564) anti-Zinc Finger and BTB Domain Containing 33 (ZBTB33) (AA 564-674) antibody (Image 2)
Background publications Zhigalova, Zhenilo, A?tkhozhina, Prokhorchuk: "[Bifunctional role of domain zinc fingers of methyl-DNA-binding protein Kaiso]." in: Molekuliarnaia biologiia, Vol. 44, Issue 2, pp. 263-74, 2010 (PubMed).

Dai, Wang, Jiang, Zhang, Dong, Wei, Xu, Li, Zhao, Wang: "Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn." in: Lung cancer (Amsterdam, Netherlands), Vol. 67, Issue 2, pp. 205-15, 2010 (PubMed).

Sowa, Bennett, Gygi, Harper: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Dai, Wang, Miao, Zhao, Zhang, Jiang, Zhang, Yang, Wang: "Cytoplasmic Kaiso is associated with poor prognosis in non-small cell lung cancer." in: BMC cancer, Vol. 9, pp. 178, 2009 (PubMed).

Kantidze, Kamalyukova, Razin: "Association of the mammalian transcriptional regulator kaiso with centrosomes and the midbody." in: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 14, pp. 2303-4, 2009 (PubMed).