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  • 产品名称：anti-CACNA1Aantibody(CalciumChannel,Voltage-Dependent,P/QType,alpha1ASubunit)(A

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简单介绍：
anti-CACNA1Aantibody(CalciumChannel,Voltage-Dependent,P/QType,alpha1ASubunit)(AA865-881)
详情介绍：
Immunogen Peptide corresponding to amino acid residues 865-881 of rat CaV2.1. Intracellular loop between domains II and III.
Sequence (C)PSSPERAPGR EGPYGRE
Cross-Reactivity (Details) Mouse - AA 16-17 residues identical, human - AA 16-17 residues identical.
Characteristics Peptide Confirmation:
Confirmed by mass-spectrography and amino acid analysis.

Antibody concentration after reconstitution:
0.8 mg/mL.

Preadsorption Control:
1 μg peptide per 10 μg antibody.

GPCR
Purification Affinity purified on immobilized antigen.
Alternative Name CaV2.1 (CACNA1A Antibody Abstract)
Background Synonyms:
Alpha1A, Cacna1a

Voltage dependent Ca2+ channels (Cav channels) are pivotal players in many physiological roles such as secretion, contraction migration and excitation. The voltage dependent calcium channels are composed of several subunits, alpha1, beta, alpha2δ and gamma. Cav channels were originally divided into six physiological types: L, N , P, Q, R, and T type. The Cav2.1 (formally named alpha1A) makes up the alpha1 poreforming subunit in P/Q type Ca2+ channel family. It is expressed preferentially in the central nervous system where along with Cav2.2 is responsible for pre-synaptic Ca2+ influx and neurotransmitter release. Mutations in the Cav2.1 have been shown to cause several neurological disorders among them are familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6 (SCA6). The involvement of Cav2.1 in synaptic transmission was assessed by using ω-Agatoxin IVA, a specific blocker of the Cav2.1 channel. The blocking sensitivity is dependent on the a subunit isoform and on the splice variant.
Gene ID 25398
UniProt P54282
Pathways Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
Application Notes Recommended Dilution:
WB: approx. 1:200,
IHC: approx. 1:100
Restrictions For Research Use only
Format Lyophilized
Reconstitution 0.2 mL deionized water.
Handling Advice Avoid multiple freezing and thawing.
Centrifuge all antibody preparations before use (10000 x g 5 min).
Storage 4 °C/-20 °C
Storage Comment The reconstituted solution can be stored at 4 °C for up to 2 weeks. For longer periods, it is recommended to add glycerol at a ratio of 1:1 and to keep the antibody solution at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) (AA 865-881), (Intracellular) antibody (ABIN1742170) Western blot analysis of rat brain membranes: 1. Anti-CaV2.1 antibody, (1:200). 2. An...
Immunohistochemistry (IHC) image for anti-Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) (AA 865-881), (Intracellular) antibody (ABIN1742170) Expression of Cav2.1 in mouse cerebellum Immunohistochemical staining of mouse cerebe...
Background publications Scheuber, Miles, Poncer: "Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 46, pp. 10402-9, 2004 (PubMed).

Tottene, Fellin, Pagnutti, Luvisetto, Striessnig, Fletcher, Pietrobon: "Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 20, pp. 13284-9, 2002 (PubMed).

Bourinet, Soong, Sutton, Slaymaker, Mathews, Monteil, Zamponi, Nargeot, Snutch: "Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels." in: Nature neuroscience, Vol. 2, Issue 5, pp. 407-15, 1999 (PubMed).