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  • 产品名称：anti-NEIL3antibody(NeiEndonucleaseVIII-Like3(E.Coli))(AA292-320)

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简单介绍：
anti-NEIL3antibody(NeiEndonucleaseVIII-Like3(E.Coli))(AA292-320)
详情介绍：
Immunogen This NEIL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human NEIL3.
Clone RB40413
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name NEIL3 (NEIL3 Antibody Abstract)
Background NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.

Synonyms: NEIL3, Endonuclease 8-like 3, DNA glycosylase FPG2, DNA glycosylase/AP lyase Neil3, Endonuclease VIII-like 3, Nei-like protein 3
NCBI Accession NP_060718
UniProt Q8TAT5
Pathways DNA Damage Repair
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) (AA 292-320), (Center) antibody (ABIN1881574) NEIL3 Antibody (Center) (ABIN1881574) western blot analysis in HL-60 cell line lysate...
Background publications Krokeide, Bolstad, Laerdahl, Bjørås, Luna: "Expression and purification of NEIL3, a human DNA glycosylase homolog." in: Protein expression and purification, Vol. 65, Issue 2, pp. 160-4, 2009 (PubMed).

Takao, Oohata, Kitadokoro, Kobayashi, Iwai, Yasui, Yonei, Zhang: "Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 14, Issue 2, pp. 261-70, 2009 (PubMed).

Dallosso, Dolwani, Jones, Jones, Colley, Maynard, Idziaszczyk, Humphreys, Arnold, Donaldson, Eccles, Ellis, Evans, Frayling, Hes, Houlston, Maher, Nielsen, Parry, Tyler, Moskvina, Cheadle, Sampson: "Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3." in: Gut, Vol. 57, Issue 9, pp. 1252-5, 2008 (PubMed).

Bethke, Murray, Webb, Schoemaker, Muir, McKinney, Hepworth, Dimitropoulou, Lophatananon, Feychting, Lönn, Ahlbom, Malmer, Henriksson, Auvinen, Kiuru, Salminen, Johansen, Christensen et al.: "Comprehensive analysis of DNA repair gene variants and risk of meningioma...." in: Journal of the National Cancer Institute, Vol. 100, Issue 4, pp. 270-6, 2008 (PubMed).

Bandaru, Sunkara, Wallace, Bond: "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII." in: DNA repair, Vol. 1, Issue 7, pp. 517-29, 2003 (PubMed).