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  • 产品名称：anti-TRIM22antibody(TripartiteMotifContaining22)(AA67-96)

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简单介绍：
anti-TRIM22antibody(TripartiteMotifContaining22)(AA67-96)
详情介绍：
Immunogen This TRIM22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human TRIM22.
Clone RB33242
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name TRIM22 (TRIM22 Antibody Abstract)
Background The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.

Synonyms: TRIM22, RNF94, STAF50, E3 ubiquitin-protein ligase TRIM22, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22
NCBI Accession NP_006065, NP_001186502
UniProt Q8IYM9
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Tripartite Motif Containing 22 (TRIM22) (AA 67-96), (N-Term) antibody (ABIN1881901) TRIM22 Antibody (N-term) (ABIN1881901) western blot analysis in A549 cell line lysate...
Product cited in: Kajaste-Rudnitski, Pultrone, Marzetta, Ghezzi, Coradin, Vicenzi: "Restriction factors of retroviral replication: the example of Tripartite Motif (TRIM) protein 5 alpha and 22." in: Amino acids, Vol. 39, Issue 1, pp. 1-9, 2010 (PubMed).

Petersson, Lönnbro, Herr, Mörgelin, Gullberg, Drott: "The human IFN-inducible p53 target gene TRIM22 colocalizes with the centrosome independently of cell cycle phase." in: Experimental cell research, Vol. 316, Issue 4, pp. 568-79, 2010 (PubMed).

Ovsyannikova, Dhiman, Haralambieva, Vierkant, OByrne, Jacobson, Poland: "Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes." in: Human genetics, Vol. 127, Issue 2, pp. 207-21, 2010 (PubMed).

Ovsyannikova, Haralambieva, Dhiman, OByrne, Pankratz, Jacobson, Poland: "Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination." in: The Journal of infectious diseases, Vol. 201, Issue 2, pp. 207-13, 2009 (PubMed).

Gao, Duan, Xu, Xiong: "Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain." in: Hepatology (Baltimore, Md.), Vol. 50, Issue 2, pp. 424-33, 2009 (PubMed).