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  • 产品名称：anti-PINK1antibody(PTENInducedPutativeKinase1)(AA237-266)

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简单介绍：
anti-PINK1antibody(PTENInducedPutativeKinase1)(AA237-266)
详情介绍：
Immunogen This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human PINK1 (PARK6).
Clone RB7383
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name PINK1 (PARK6) (PINK1 Antibody Abstract)
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Synonyms: PINK1, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1
NCBI Accession NP_115785
UniProt Q9BXM7
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-PTEN Induced Putative Kinase 1 (PINK1) (AA 237-266), (Center) antibody (ABIN1882117) The anti-PINK1 C-term Pab (ABIN1882117) is used in Western blot to detect PINK1 in mo...
Western Blotting (WB) image for anti-PTEN Induced Putative Kinase 1 (PINK1) (AA 237-266), (Center) antibody (ABIN1882117) The anti-PINK1 C-term Pab (ABIN1882117) is used in Western blot to detect PINK1 in mo...
Product cited in: Mannam, Shinn, Srivastava, Neamu, Walker, Bohanon, Merkel, Kang, Dela Cruz, Ahasic, Pisani, Trentalange, West, Shadel, Elias, Lee: "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 7, pp. L604-19, 2014 (PubMed).

Geisler, Holmström, Skujat, Fiesel, Rothfuss, Kahle, Springer: "PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1." in: Nature cell biology, Vol. 12, Issue 2, pp. 119-31, 2010 (PubMed).

Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: "Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease." in: Archives of neurology, Vol. 61, Issue 12, pp. 1898-904, 2004 (PubMed).

Hatano, Li, Sato, Asakawa, Yamamura, Tomiyama, Yoshino, Asahina, Kobayashi, Hassin-Baer, Lu, Ng, Rosales, Shimizu, Toda, Mizuno, Hattori: "Novel PINK1 mutations in early-onset parkinsonism." in: Annals of neurology, Vol. 56, Issue 3, pp. 424-7, 2004 (PubMed).