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  • 产品名称：anti-TXNRD3antibody(ThioredoxinReductase3)(AA304-333)

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简单介绍：
anti-TXNRD3antibody(ThioredoxinReductase3)(AA304-333)
详情介绍：
Immunogen This TXNRD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human TXNRD3.
Clone RB40894
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name TXNRD3 (TXNRD3 Antibody Abstract)
Background This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: TXNRD3, TGR, TRXR3, Thioredoxin reductase 3, Thioredoxin and glutathione reductase, Thioredoxin reductase TR2
NCBI Accession NP_001166984, NP_443115
UniProt Q86VQ6
Pathways Cell RedoxHomeostasis
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Thioredoxin Reductase 3 (TXNRD3) (AA 304-333), (Center) antibody (ABIN1881963) TXNRD3 Antibody (Center) (ABIN1881963) western blot analysis in MDA-MB453 cell line l...
Product cited in: Gerashchenko, Su, Gladyshev: "CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes." in: The Journal of biological chemistry, Vol. 285, Issue 7, pp. 4595-602, 2010 (PubMed).

Starr, Shiels, Harris, Pattie, Pearce, Relton, Deary: "Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey." in: Mechanisms of ageing and development, Vol. 129, Issue 12, pp. 745-51, 2008 (PubMed).

Kryukov, Castellano, Novoselov, Lobanov, Zehtab, Guigó, Gladyshev: "Characterization of mammalian selenoproteomes." in: Science (New York, N.Y.), Vol. 300, Issue 5624, pp. 1439-43, 2003 (PubMed).

Sun, Kirnarsky, Sherman, Gladyshev: "Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 7, pp. 3673-8, 2001 (PubMed).