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  • 产品名称：anti-SHC(SrcHomology2DomainContaining)Family,Member4(SHC4)(AA590-617),(C-Term)a

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简单介绍：
anti-SHC(SrcHomology2DomainContaining)Family,Member4(SHC4)(AA590-617),(C-Term)antibody
详情介绍：
Immunogen This Mouse Shc4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-617 amino acids from the C-terminal region of mouse Shc4.
Clone RB40853
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Shc4 (SHC4 Antibody Abstract)
Background Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

Synonyms: Shc4, Shcd, SHC-transforming protein 4, Rai-like protein, SHC-transforming protein D, Src homology 2 domain-containing-transforming protein C4
NCBI Accession NP_950187
UniProt Q6S5L9
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-SHC (Src Homology 2 Domain Containing) Family, Member 4 (SHC4) (AA 590-617), (C-Term) antibody (ABIN1881806) Mouse Shc4 Antibody (C-term) (ABIN1881806) western blot analysis in mouse heart tissu...
Product cited in: Jones, Hardy, Friese, Jorgensen, Smith, Woody, Burden, Pawson: "Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase." in: Molecular and cellular biology, Vol. 27, Issue 13, pp. 4759-73, 2007 (PubMed).

Fagiani, Giardina, Luzi, Cesaroni, Quarto, Capra, Germano, Bono, Capillo, Pelicci, Lanfrancone: "RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas." in: Cancer research, Vol. 67, Issue 7, pp. 3064-73, 2007 (PubMed).