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  • 产品名称：anti-Lrig1antibody(Leucine-RichRepeatsandImmunoglobulin-LikeDomains1)(AA801-829

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简单介绍：
anti-Lrig1antibody(Leucine-RichRepeatsandImmunoglobulin-LikeDomains1)(AA801-829)
详情介绍：
Immunogen This LRIG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 801-829 amino acids from the C-terminal region of human LRIG1.
Clone RB40253
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name LRIG1 (Lrig1 Antibody Abstract)
Background LRIG1 act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

Synonyms: LRIG1, LIG1, Leucine-rich repeats and immunoglobulin-like domains protein 1
NCBI Accession NP_056356
UniProt Q96JA1
Research Area Cancer
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 801-829), (C-Term) antibody (ABIN1881506) LRIG1 Antibody (C-term) (ABIN1881506) western blot analysis in mouse stomach tissue l...
Product cited in: Ye, Gao, Xu, Zeng, Ou, Mao, Wang, He, Wang, Yang, Guo, Lei: "Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity." in: Journal of neuro-oncology, Vol. 94, Issue 2, pp. 183-94, 2009 (PubMed).

Background publications Stutz, Shattuck, Laederich, Carraway, Sweeney: "LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII." in: Oncogene, Vol. 27, Issue 43, pp. 5741-52, 2008 (PubMed).