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  • 产品名称：anti-UDPGlucuronosyltransferase2Family,PolypeptideB4(UGT2B4)(AA68-96),(N-Term)a

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简单介绍：
anti-UDPGlucuronosyltransferase2Family,PolypeptideB4(UGT2B4)(AA68-96),(N-Term)antibody
详情介绍：
Immunogen This UGT2B4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the N-terminal region of human UGT2B4.
Clone RB41766
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name UGT2B4 (UGT2B4 Antibody Abstract)
Background UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Synonyms: UGT2B4, UGT2B11, UDP-glucuronosyltransferase 2B4, HLUG25, Hyodeoxycholic acid-specific UDPGT, UDPGTh-1
NCBI Accession NP_066962
UniProt P06133
Research Area Cancer, Metabolism, Hormones
Pathways Steroid Hormone Biosynthesis
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-UDP Glucuronosyltransferase 2 Family, Polypeptide B4 (UGT2B4) (AA 68-96), (N-Term) antibody (ABIN1881977) UGT2B4 Antibody (N-term) (ABIN1881977) western blot analysis in MDA-MB453 cell line l...
Product cited in: Lévesque, Ménard, Laverdière, Bellemare, Barbier, Girard, Guillemette: "Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation." in: Pharmacogenetics and genomics, Vol. 20, Issue 3, pp. 195-210, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Yong, Schwartz, Atkinson, Makar, Thomas, Newton, Aiello Bowles, Holt, Leisenring, Lampe: "Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 2, pp. 537-46, 2010 (PubMed).