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  • 产品名称：anti-FMO5antibody(FlavinContainingMonooxygenase5)(AA474-502)

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简单介绍：
anti-FMO5antibody(FlavinContainingMonooxygenase5)(AA474-502)
详情介绍：
Immunogen This FMO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-502 amino acids from the C-terminal region of human FMO5.
Clone RB42789
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name FMO5 (FMO5 Antibody Abstract)
Background Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in ***** liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.

Synonyms: FMO5, Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, Hepatic flavin-containing monooxygenase 5
NCBI Accession NP_001138301, NP_001138302, NP_001452
UniProt P49326
Research Area Signaling, Metabolism
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Flavin Containing Monooxygenase 5 (FMO5) (AA 474-502), (C-Term) antibody (ABIN1881348) FMO5 Antibody (C-term) (ABIN1881348) western blot analysis in MDA-MB453 cell line lys...
Product cited in: Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, 2009 (PubMed).

Furnes, Feng, Sommer, Schlenk: "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 31, Issue 2, pp. 187-93, 2003 (PubMed).