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  • 产品名称：anti-ECSITantibody(ECSITHomolog(Drosophila))(AA396-425)

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简单介绍：
anti-ECSITantibody(ECSITHomolog(Drosophila))(AA396-425)
详情介绍：
Immunogen This ECSIT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 AA from the C-terminal region of human ECSIT.
Clone RB34997
Isotype Ig
Specificity This ECSIT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-425 amino acids from the C-terminal region of human ECSIT.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ECSIT (ECSIT Antibody Abstract)
Background Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Synonyms: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial,ECSIT,
Research Area Cell Signaling, Cell Structure
Pathways TLR Signaling, Toll-Like Receptors Cascades
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-ECSIT Homolog (Drosophila) (ECSIT) (AA 396-425), (C-Term) antibody (ABIN658778) ECSIT Antibody (C-term) (ABIN658778) western blot analysis in ZR-75-1 cell line lysat...
Background publications Vogel, Janssen, van den Brand, Dieteren, Verkaart, Koopman, Willems, Pluk, van den Heuvel, Smeitink, Nijtmans: "Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly." in: Genes & development, Vol. 21, Issue 5, pp. 615-24, 2007 (PubMed).

Xiao, Shim, Klüppel, Zhang, Dong, Flavell, Fu, Wrana, Hogan, Ghosh: "Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis." in: Genes & development, Vol. 17, Issue 23, pp. 2933-49, 2003 (PubMed).

Kopp, Medzhitov, Carothers, Xiao, Douglas, Janeway, Ghosh: "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway." in: Genes & development, Vol. 13, Issue 16, pp. 2059-71, 1999 (PubMed).