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  • 产品名称：anti-CyclinB1antibody(CCNB1)(pSer35)

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简单介绍：
anti-CyclinB1antibody(CCNB1)(pSer35)
详情介绍：
Immunogen This CCNB1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S35 of human CCNB1.
Clone RB42141
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CCNB1 (CCNB1 Antibody Abstract)
Background The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq].

Synonyms: CCNB1, CCNB, G2/mitotic-specific cyclin-B1
NCBI Accession NP_114172
UniProt P14635
Pathways Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, M Phase
Application Notes WB: 1:1100,DB: 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Dot Blot (DB) image for anti-Cyclin B1 (CCNB1) (pSer35) antibody (ABIN1881155) Dot blot analysis of CCNB1 Antibody (Phospho S35) Phospho-specific Pab (ABIN1881155) ...
Western Blotting (WB) image for anti-Cyclin B1 (CCNB1) (pSer35) antibody (ABIN1881155) Dot blot analysis of CCNB1 Antibody (Phospho S35) Phospho-specific Pab (ABIN1881155) ...
Product cited in: Kreis, Sanhaji, Krämer, Sommer, Rödel, Strebhardt, Yuan: "Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells." in: Oncogene, Vol. 29, Issue 41, pp. 5591-603, 2010 (PubMed).

van Zon, Ogink, ter Riet, Medema, te Riele, Wolthuis: "The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 587-602, 2010 (PubMed).

Harley, Allan, Sanderson, Clarke: "Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest." in: The EMBO journal, Vol. 29, Issue 14, pp. 2407-20, 2010 (PubMed).