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  • 产品名称：anti-CHEK2antibody(CheckpointKinase2)(AA111-141)

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简单介绍：
anti-CHEK2antibody(CheckpointKinase2)(AA111-141)
详情介绍：
Immunogen This CHEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-141 amino acids from the N-terminal region of human CHEK2.
Clone RB19067
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CHEK2 (CHEK2 Antibody Abstract)
Background CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.

Synonyms: CHEK2, CDS1, CHK2, RAD53, Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2
NCBI Accession NP_009125, NP_665861, NP_001244316, NP_001005735
UniProt O96017
Pathways p53 Signaling, Apoptosis, Cell Division Cycle
Application Notes WB: 1:1000,IHC (p): 1:50-100,FACS: 1:10-50,IF: 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibody (ABIN1881196) CHEK2 Antibody (N-term) (ABIN1881196) flow cytometric analysis of K562 cells (right h...
Flow Cytometry (FACS) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibody (ABIN1881196) CHEK2 Antibody (N-term) (ABIN1881196) flow cytometric analysis of K562 cells (right h...
Immunohistochemistry (IHC) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibody (ABIN1881196) CHEK2 Antibody (N-term) (ABIN1881196) flow cytometric analysis of K562 cells (right h...
Immunofluorescence (IF) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibody (ABIN1881196) CHEK2 Antibody (N-term) (ABIN1881196) flow cytometric analysis of K562 cells (right h...
Product cited in: Yang, Wood, Hrushesky: "Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control." in: The Journal of biological chemistry, Vol. 285, Issue 5, pp. 3030-4, 2010 (PubMed).

Varmark, Kwak, Theurkauf: "A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells." in: Cell cycle (Georgetown, Tex.), Vol. 9, Issue 2, pp. 312-20, 2010 (PubMed).

Zhu, Miao, Huang, Feng, Zhang, Lu, Cai, Tong, Xu, Qian, Ding: "Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 11, pp. 1226-34, 2009 (PubMed).