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  • 产品名称：anti-Achaete-ScuteComplexHomolog1(Drosophila)(ASCL1)(AA63-90),(N-Term)antibody

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简单介绍：
anti-Achaete-ScuteComplexHomolog1(Drosophila)(ASCL1)(AA63-90),(N-Term)antibody
详情介绍：
Immunogen This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.
Clone RB41522
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name ASCL1 (ASCL1 Antibody Abstract)
Background This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Synonyms: ASCL1, ASH1, BHLHA46, HASH1, Achaete-scute homolog 1, Class A basic helix-loop-helix protein 46
NCBI Accession NP_004307
UniProt P50553
Pathways Dopaminergic Neurogenesis
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 63-90), (N-Term) antibody (ABIN1881074) ASCL1 Antibody (N-term) (ABIN1881074) western blot analysis in NCI-H460 cell line lys...
Product cited in: Phi, Kim, Eun, Wang, Park, Choi, Kim, Park, Cho, Kim: "Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas." in: Journal of neurosurgery. Pediatrics, Vol. 5, Issue 6, pp. 608-14, 2010 (PubMed).

McGaughey, McCallion: "Efficient discovery of ASCL1 regulatory sequences through transgene pooling." in: Genomics, Vol. 95, Issue 6, pp. 363-9, 2010 (PubMed).

Li, Zhong, Li, Huang, Wang, Zheng, Zhang: "[Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors]." in: Zhongguo fei ai za zhi = Chinese journal of lung cancer, Vol. 13, Issue 4, pp. 317-21, 2010 (PubMed).

Deng, Yang, Le, Deng, Xu, Xiong, Zhu, Xie, Song, Jankovic: "Examination of the MASH1 gene in patients with Parkinson's disease." in: Biochemical and biophysical research communications, Vol. 392, Issue 4, pp. 548-50, 2010 (PubMed).

Improgo, Schlichting, Cortes, Zhao-Shea, Tapper, Gardner: "ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus." in: Molecular cancer research : MCR, Vol. 8, Issue 2, pp. 194-203, 2010 (PubMed).