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  • 产品名称：anti-PTPN6antibody(Protein-tyrosinePhosphatase1C)(AA247-277)

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简单介绍：
anti-PTPN6antibody(Protein-tyrosinePhosphatase1C)(AA247-277)
详情介绍：
Immunogen This PTPN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-277 amino acids from the Central region of human PTPN6.
Clone RB17225
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name PTPN6 (PTPN6 Antibody Abstract)
Background PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.

Synonyms: PTPN6, HCP, PTP1C, Tyrosine-protein phosphatase non-receptor type 6, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1
NCBI Accession NP_002822, NP_536859, NP_536858
UniProt P29350
Pathways JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2
Application Notes IF: 1:100,WB: 1:1000,IHC (p): 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Immunofluorescence (IF) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 247-277), (Center) antibody (ABIN1882123) Western blot analysis of PTPN6 Antibody (Center) (ABIN1882123) in HL-60 cell line lys...
Western Blotting (WB) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 247-277), (Center) antibody (ABIN1882123) Western blot analysis of PTPN6 Antibody (Center) (ABIN1882123) in HL-60 cell line lys...
Western Blotting (WB) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 247-277), (Center) antibody (ABIN1882123) Western blot analysis of PTPN6 Antibody (Center) (ABIN1882123) in HL-60 cell line lys...
Product cited in: Korporaal, Koekman, Verhoef, van der Wal, Bezemer, Van Eck, Akkerman: "Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 3, pp. 372-9, 2009 (PubMed).

Cho, Oh, Zhu: "Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 4, pp. 412-9, 2008 (PubMed).