anti-Phospholambanantibody(PLN)(N-Term) 抗体网

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产品名称：anti-Phospholambanantibody(PLN)(N-Term)
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anti-Phospholambanantibody(PLN)(N-Term)

详情介绍：

Product Details anti-Phospholamban Antibody
Product Details anti-Phospholamban Antibody
Immunogen	This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.
Clone	RB44799
Predicted Reactivity	Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus),Rabbit
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification. Purified Rabbit Polyclonal Antibody (Pab)

Target Details Phospholamban
Target Details Phospholamban
Alternative Name	PLN (PLN Antibody Abstract)
Background	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Synonyms: Cardiac phospholamban, PLB, PLN, PLB
UniProt	P26678
Pathways	Negative Regulation of Transporter Activity

Application Details
Application Details
Application Notes	WB: 1:1000
Restrictions	For Research Use only

Handling
Handling
Format	Liquid
Concentration	0.39 mg/mL
Buffer	Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative	Sodium azide
Precaution of Use	WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Images
Images
Supplier Images	Western blot analysis of lysate from U266 cell line,using PLN Antibody (N-term) (ABIN... Western blot analysis of lysate from U266 cell line,using PLN Antibody (N-term) (ABIN1882182). AP20550a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. Western blot analysis of lysate from U266 cell line,using PLN Antibody (N-term) (ABIN1882182). AP20550a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

References for anti-Phospholamban antibody (ABIN1882182)
References for anti-Phospholamban antibody (ABIN1882182)
Product cited in:	Kaliman, Catalucci, Lam, Kondo, Gutiérrez, Reddy, Palacín, Zorzano, Chien, Ruiz-Lozano: "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 8016-21, 2005 (PubMed). Minamisawa, Sato, Tatsuguchi, Fujino, Imamura, Uetsuka, Nakazawa, Matsuoka: "Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy." in: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 1-4, 2003 (PubMed). McTiernan, Frye, Lemster, Kinder, Ogletree-Hughes, Moravec, Feldman: "The human phospholamban gene: structure and expression." in: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 679-92, 1999 (PubMed). Fujii, Zarain-Herzberg, Willard, Tada, MacLennan: "Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11669-75, 1991 (PubMed).