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  • 产品名称：anti-FilaminAantibody(FilaminA,alpha)

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简单介绍：
anti-FilaminAantibody(FilaminA,alpha)
详情介绍：
Immunogen Purified His-tagged FLNA protein was used to produced this monoclonal antibody.
Clone 1273CT424-104-153
Isotype IgG1
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name FLNA (FLNA Antibody Abstract)
Background Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.

Synonyms: FLNA,FLN, FLN1, Filamin-A, Filamin-A, Actin-binding protein 280, Filamin-A, Alpha-filamin, Filamin-A, Endothelial actin-binding protein, Filamin-A, Filamin-1, Filamin-A, Non-muscle filamin
NCBI Accession NP_001104026, NP_001447
UniProt P21333
Pathways TCR Signaling, Maintenance of Protein Location
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.44 mg/mL
Buffer Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Filamin A, alpha (FLNA) antibody (ABIN1882243) FLNA Antibody (ABIN1882243) western blot analysis in PC-3, rat C6 cell line lysates (...
Product cited in: Campos, Rodriguez, Machado Leopoldino, Hait, Lopez Bergami, Castro, Sanchez, Maceyka, Spiegel, Alvarez: "Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-?B Activation in Melanoma Cells by Inhibition of Akt Signaling." in: Molecular and cellular biology, 2015 (PubMed).

Li, Liu, Wang, Liu, Liu, Li, Wan, Wang, Zhang, Jin, Liu, Zhu, Liu: "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 11, pp. 2517-28, 2010 (PubMed).

Chen, Zollo, Mazzarella, Ciccodicola, Chen, Zuo, Heiner, Burough, Repetto, Schlessinger, DUrso: "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci." in: Human molecular genetics, Vol. 5, Issue 5, pp. 659-68, 1997 (PubMed).

Patrosso, Repetto, Villa, Milanesi, Frattini, Faranda, Mancini, Maestrini, Toniolo, Vezzoni: "The exon-intron organization of the human X-linked gene (FLN1) encoding actin-binding protein 280." in: Genomics, Vol. 21, Issue 1, pp. 71-6, 1994 (PubMed).

Gorlin, Yamin, Egan, Stewart, Stossel, Kwiatkowski, Hartwig: "Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring." in: The Journal of cell biology, Vol. 111, Issue 3, pp. 1089-105, 1990 (PubMed).

Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).