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  • 产品名称：anti-ORC3antibody(OriginRecognitionComplex,Subunit3)(AA17-46)

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简单介绍：
anti-ORC3antibody(OriginRecognitionComplex,Subunit3)(AA17-46)
详情介绍：
Immunogen This ORC3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 AA from the N-terminal region of human ORC3L.
Clone RB35037
Isotype Ig
Specificity This ORC3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human ORC3L.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ORC3L (ORC3 Antibody Abstract)
Background The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Synonyms: Origin recognition complex subunit 3,ORC3L,LATHEO, ORC3
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Chromatin, Cell Structure
Pathways Mitotic G1-G1/S Phases, DNA Replication, Feeding Behaviour, Synthesis of DNA
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Origin Recognition Complex, Subunit 3 (ORC3) (AA 17-46), (N-Term) antibody (ABIN658794) ORC3L Antibody (N-term) (ABIN658794) western blot analysis in Hela cell line lysates ...
Background publications Enjuanes, Benavente, Bosch, Martín-Guerrero, Colomer, Pérez-Alvarez, Reina, Ardanaz, Jares, García-Orad, Pujana, Montserrat, de Sanjosé, Campo: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).

Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).