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  • 产品名称：anti-CD46Molecule,ComplementRegulatoryProtein(CD46)(AA330-361),(Center),(Tyr354

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简单介绍：
anti-CD46Molecule,ComplementRegulatoryProtein(CD46)(AA330-361),(Center),(Tyr354)antibody
详情介绍：
Immunogen This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CD46 (CD46 Antibody Abstract)
Background Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Synonyms: CD46,Membrane cofactor protein
NCBI Accession NP_758863, NP_002380, NP_758869, NP_722548, NP_758871, NP_758860, NP_758861, NP_758862
UniProt P15529
Research Area Immunology, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Actin Filament Polymerization
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-CD46 Molecule, Complement Regulatory Protein (CD46) (AA 330-361), (Center), (Tyr354) antibody (ABIN1881186) CD46 Antibody (Y354) (ABIN1881186) western blot analysis in A549,Hela cell line lysat...
Product cited in: Riley, Kemper, Leung, Atkinson: "Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." in: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, 2002 (PubMed).

Cervoni, Fenichel, Akhoundi, Hsi, Rossi: "Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)." in: Molecular reproduction and development, Vol. 34, Issue 1, pp. 107-13, 1993 (PubMed).

Post, Liszewski, Adams, Tedja, Miller, Atkinson: "Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype." in: The Journal of experimental medicine, Vol. 174, Issue 1, pp. 93-102, 1991 (PubMed).

Purcell, Russell, Deacon, Brown, Hooker, McKenzie: "Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation." in: Immunogenetics, Vol. 33, Issue 5-6, pp. 335-44, 1991 (PubMed).

Lublin, Liszewski, Post, Arce, Le Beau, Rebentisch, Lemons, Seya, Atkinson: "Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins." in: The Journal of experimental medicine, Vol. 168, Issue 1, pp. 181-94, 1988 (PubMed).