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  • 产品名称：anti-Netrin1antibody(NTN1)(AA568-596)

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简单介绍：
anti-Netrin1antibody(NTN1)(AA568-596)
详情介绍：
Immunogen This NTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 568-596 amino acids from the C-terminal region of human NTN1.
Clone RB44404
Predicted Reactivity Chicken,Mouse (Murine),Pig (Porcine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name NTN1 (NTN1 Antibody Abstract)
Background Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Synonyms: NTN1,NTN1L, Netrin-1, Netrin-1, Epididymis tissue protein Li 131P
NCBI Accession NP_004813
UniProt O95631
Pathways Regulation of Cell Size
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Netrin 1 (NTN1) (AA 568-596), (C-Term) antibody (ABIN1881590) NTN1 Antibody (C-term) (ABIN1881590) western blot analysis in U87-MG cell line lysate...
Product cited in: Li, Liu, Wang, Liu, Liu, Li, Wan, Wang, Zhang, Jin, Liu, Zhu, Liu: "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 11, pp. 2517-28, 2010 (PubMed).

Liu, Li, Wang, Kar, Guan, Rao, Wu: "DSCAM functions as a netrin receptor in commissural axon pathfinding." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 8, pp. 2951-6, 2009 (PubMed).

Mazelin, Bernet, Bonod-Bidaud, Pays, Arnaud, Gespach, Bredesen, Scoazec, Mehlen: "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis." in: Nature, Vol. 431, Issue 7004, pp. 80-4, 2004 (PubMed).

Meyerhardt, Caca, Eckstrand, Hu, Lengauer, Banavali, Look, Fearon: "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 1, pp. 35-42, 1999 (PubMed).

Background publications Zody, Garber, Adams, Sharpe, Harrow, Lupski, Nicholson, Searle, Wilming, Young, Abouelleil, Allen, Bi, Bloom, Borowsky, Bugalter, Butler, Chang, Chen, Cook, Corum, Cuomo, de Jong, DeCaprio, Dewar et al.: "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. ..." in: Nature, Vol. 440, Issue 7087, pp. 1045-9, 2006 (PubMed).