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  • 产品名称：anti-ZRSR2antibody(ZincFinger(CCCHType),RNA-BindingMotifandserine/arginineRich2

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  • 产品厂商：半导体
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简单介绍：
anti-ZRSR2antibody(ZincFinger(CCCHType),RNA-BindingMotifandserine/arginineRich2)(AA453-482)
详情介绍：
Immunogen This ZRSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the C-terminal region of human ZRSR2.
Clone RB44050
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name ZRSR2 (ZRSR2 Antibody Abstract)
Background Pre-mRNA-binding protein required for splicing of both U2-and U12-type introns. Selectively interacts with the 3'-splice site of U2-and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Synonyms: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2,U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, Renal carcinoma antigen NY-REN-20, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, U2(RNU2) small nuclear RNA auxiliary factor 1-like 2, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, U2AF35-related protein
NCBI Accession NP_005080
UniProt Q15696
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Pathways Ribonucleoprotein Complex Subunit Organization
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Zinc Finger (CCCH Type), RNA-Binding Motif and serine/arginine Rich 2 (ZRSR2) (AA 453-482), (C-Term) antibody (ABIN1882041) ZRSR2 Antibody (C-term) (ABIN1882041) western blot analysis in 293,HepG2,HL-60,Jurkat...
Background publications Ross, Grafham, Coffey, Scherer, McLay, Muzny, Platzer, Howell, Burrows, Bird, Frankish, Lovell, Howe, Ashurst, Fulton, Sudbrak, Wen, Jones, Hurles, Andrews, Scott, Searle, Ramser, Whittaker, Deadman et al.: "The DNA sequence of the human X chromosome. ..." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Product cited in: Will, Schneider, Hossbach, Urlaub, Rauhut, Elbashir, Tuschl, Lührmann: "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome." in: RNA (New York, N.Y.), Vol. 10, Issue 6, pp. 929-41, 2004 (PubMed).

Scanlan, Gordan, Williamson, Stockert, Bander, Jongeneel, Gure, Jäger, Jäger, Knuth, Chen, Old: "Antigens recognized by autologous antibody in patients with renal-cell carcinoma." in: International journal of cancer. Journal international du cancer, Vol. 83, Issue 4, pp. 456-64, 1999 (PubMed).

Tronchère, Wang, Fu: "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA." in: Nature, Vol. 388, Issue 6640, pp. 397-400, 1997 (PubMed).

Kitagawa, Wang, Hatada, Yamaoka, Nojima, Inazawa, Abe, Mitsuya, Oshimura, Murata: "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1." in: Genomics, Vol. 30, Issue 2, pp. 257-63, 1996 (PubMed).