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  • 产品名称：anti-PeptidylprolylCis/transIsomerase,NIMA-Interacting1(PIN1)antibody

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简单介绍：
anti-PeptidylprolylCis/transIsomerase,NIMA-Interacting1(PIN1)antibody
详情介绍：
Immunogen Purified His-tagged PIN1 protein was used to produced this monoclonal antibody.
Clone 855CT1-7-5
Isotype IgG1
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name PIN1 (PIN1 Antibody Abstract)
Background Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.

Synonyms: PIN1,Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Rotamase Pin1
NCBI Accession NP_006212
UniProt Q13526
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) antibody (ABIN1882275) PIN1 Antibody (ABIN1882275) western blot analysis in Hela,293,mouse NIH/3T3,PC-12,COS...
Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).