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  • 产品名称：anti-E-cadherinantibody(Cadherin1,Type1,E-Cadherin(Epithelial))

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  • 产品厂商：半导体
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简单介绍：
anti-E-cadherinantibody(Cadherin1,Type1,E-Cadherin(Epithelial))
详情介绍：
Immunogen Purified His-tagged CDH1 protein was used to produced this monoclonal antibody.
Clone 813CT11-1-3
Isotype IgG1
Purification Ascites
Alternative Name CDH1 (CDH1 Antibody Abstract)
Background Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Synonyms: CDH1,CDHE, UVO, E-Cad/CTF3, Cadherin-1, Cadherin-1, CAM 120/80, Cadherin-1, Epithelial cadherin, Cadherin-1, Uvomorulin, Cadherin-1, CD_antigen=CD324, E-Cad/CTF1, E-Cad/CTF2
NCBI Accession NP_004351
UniProt P12830
Research Area Proteolysis / Ubiquitin
Pathways Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
Application Notes WB: 1:5000
Restrictions For Research Use only
Format Liquid
Buffer Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody (ABIN1882221) CDH1 Antibody (ABIN1882221) western blot analysis in MCF-7 cell line lysates (35 µg/l...
Product cited in: Ito, Okamoto, Araki, Kawano, Nakao, Fujiyama, Tomita, Mimori, Saya: "Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts." in: Oncogene, Vol. 18, Issue 50, pp. 7080-90, 2000 (PubMed).

Oda, Kanai, Oyama, Yoshiura, Shimoyama, Birchmeier, Sugimura, Hirohashi: "E-cadherin gene mutations in human gastric carcinoma cell lines." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1858-62, 1994 (PubMed).

Rimm, Morrow: "Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily." in: Biochemical and biophysical research communications, Vol. 200, Issue 3, pp. 1754-61, 1994 (PubMed).

Bussemakers, Giroldi, van Bokhoven, Schalken: "Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter." in: Biochemical and biophysical research communications, Vol. 203, Issue 2, pp. 1284-90, 1994 (PubMed).

Bussemakers, van Bokhoven, Mees, Kemler, Schalken: "Molecular cloning and characterization of the human E-cadherin cDNA." in: Molecular biology reports, Vol. 17, Issue 2, pp. 123-8, 1993 (PubMed).