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  • 产品名称：anti-Calcium/calmodulin-DependentserineProteinKinase(MAGUKFamily)(CASK)(AA589-6

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简单介绍：
anti-Calcium/calmodulin-DependentserineProteinKinase(MAGUKFamily)(CASK)(AA589-616),(Center)antibody
详情介绍：
Immunogen This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask.
Predicted Reactivity Human,Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Cask (CASK Antibody Abstract)
Background Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Synonyms: Cask,Peripheral plasma membrane protein CASK, Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase
NCBI Accession NP_071520
UniProt Q62915
Pathways Synaptic Vesicle Exocytosis
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.26 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 589-616), (Center) antibody (ABIN1881710) Rat Cask Antibody (Center) (ABIN1881710) western blot analysis in rat brain tissue ly...
Product cited in: Tabuchi, Biederer, Butz, Sudhof: "CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 11, pp. 4264-73, 2002 (PubMed).

Chetkovich, Bunn, Kuo, Kawasaki, Kohwi, Bredt: "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 15, pp. 6415-25, 2002 (PubMed).

Hsueh, Wang, Yang, Sheng: "Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2." in: Nature, Vol. 404, Issue 6775, pp. 298-302, 2000 (PubMed).

Butz, Okamoto, Südhof: "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain." in: Cell, Vol. 94, Issue 6, pp. 773-82, 1998 (PubMed).

Hata, Butz, Südhof: "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2488-94, 1996 (PubMed).