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  • 产品名称：anti-EGFRantibody(EpidermalGrowthFactorReceptor)(pSer1070)

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简单介绍：
anti-EGFRantibody(EpidermalGrowthFactorReceptor)(pSer1070)
详情介绍：
Immunogen This EGFR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pSer1070 of human EGFR.
Clone RB12735
Isotype Ig
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name EGFR (EGFR Antibody Abstract)
Background Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. EGFR is a receptor for EGF, but also for other members of the EGF family, including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.
Synonyms: EGFR, ERBB, ERBB1, HER1, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Molecular Weight 134277 Da
Gene ID 1956
NCBI Accession NP_005219, NP_958439, NP_958440, NP_958441
UniProt P00533
Research Area Cancer, Tyrosine Kinases, Growth Factors, Hormones, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
Application Notes WB - 1:1000,DB - 1:500
Restrictions For Research Use only
Format Liquid
Concentration 440 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Product cited in: Aifa, Aydin, Nordvall, Lundström, Svensson, Hermanson: "A basic peptide within the juxtamembrane region is required for EGF receptor dimerization." in: Experimental cell research, Vol. 302, Issue 1, pp. 108-14, 2004 (PubMed).

Adams, McKern, Ward: "Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor." in: Growth factors (Chur, Switzerland), Vol. 22, Issue 2, pp. 89-95, 2004 (PubMed).

Ichinose, Murata, Yanagida, Sako: "EGF signalling amplification induced by dynamic clustering of EGFR." in: Biochemical and biophysical research communications, Vol. 324, Issue 3, pp. 1143-9, 2004 (PubMed).

Kuribayashi, Kataoka, Kurabayashi, Miura: "Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells." in: Endocrinology, Vol. 145, Issue 11, pp. 4976-84, 2004 (PubMed).

Kapoor, Zhan, Johnson, ORourke: "Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 823-36, 2003 (PubMed).