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  • 产品名称：anti-UCHL5antibody(UbiquitinCarboxyl-terminalHydrolaseL5)(AA136-164)

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简单介绍：
anti-UCHL5antibody(UbiquitinCarboxyl-terminalHydrolaseL5)(AA136-164)
详情介绍：
Immunogen This UCHL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the Central region of human UCHL5.
Clone RB42329
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name UCHL5 (UCHL5 Antibody Abstract)
Background Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.

Synonyms: UCHL5, UCH37, Ubiquitin carboxyl-terminal hydrolase isozyme L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5
NCBI Accession NP_001186192, NP_057068, NP_001186191, NP_001186190
UniProt Q9Y5K5
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) (AA 136-164), (Center) antibody (ABIN1881974) UCHL5 Antibody (Center) (ABIN1881974) western blot analysis in NCI-H460 cell line lys...
Product cited in: Nishio, Kim, Kawai, Mizushima, Yamane, Hamazaki, Murata, Tanaka, Morimoto: "Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain." in: Biochemical and biophysical research communications, Vol. 390, Issue 3, pp. 855-60, 2009 (PubMed).

Yao, Song, Jin, Cai, Takahashi, Swanson, Washburn, Florens, Conaway, Cohen, Conaway: "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex." in: Molecular cell, Vol. 31, Issue 6, pp. 909-17, 2008 (PubMed).

Koulich, Li, DeMartino: "Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome." in: Molecular biology of the cell, Vol. 19, Issue 3, pp. 1072-82, 2008 (PubMed).

Hamazaki, Iemura, Natsume, Yashiroda, Tanaka, Murata: "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes." in: The EMBO journal, Vol. 25, Issue 19, pp. 4524-36, 2006 (PubMed).

Qiu, Ouyang, Li, Miao, Wang, Goldberg: "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37." in: The EMBO journal, Vol. 25, Issue 24, pp. 5742-53, 2006 (PubMed).