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  • 产品名称：anti-GapJunctionProtein,alpha8,50kDa(GJA8)(AA99-130),(N-Term)antibody

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简单介绍：
anti-GapJunctionProtein,alpha8,50kDa(GJA8)(AA99-130),(N-Term)antibody
详情介绍：
Immunogen This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-130 amino acids from the N-terminal region of human Connexin 50.
Clone RB1381
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Connexin 50 (GJA8 Antibody Abstract)
Background GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.

Synonyms: GJA8, Gap junction alpha-8 protein, Connexin-50, Lens fiber protein MP70
NCBI Accession NP_005258
UniProt P48165
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1.79 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Gap Junction Protein, alpha 8, 50kDa (GJA8) (AA 99-130), (N-Term) antibody (ABIN1882072) Western blot analysis of anti-GJA8 Antibody (N-term) (ABIN1882072) in HepG2 cell line...
Product cited in: Ponsaerts, De Vuyst, Retamal, Dhondt, Vermeire, Wang, De Smedt, Zimmermann, Himpens, Vereecke, Leybaert, Bultynck: "Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 11, pp. 4378-95, 2010 (PubMed).

Shiels, Mackay, Ionides, Berry, Moore, Bhattacharya: "A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q." in: American journal of human genetics, Vol. 62, Issue 3, pp. 526-32, 1998 (PubMed).

Church, Wang, Steele: "The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping." in: Current eye research, Vol. 14, Issue 10, pp. 979-81, 1996 (PubMed).

Church, Wang, Steele: "The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping." in: Current eye research, Vol. 14, Issue 3, pp. 215-21, 1995 (PubMed).