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  • 产品名称：anti-SCNN1Bantibody(SodiumChannel,Nonvoltage-Gated1,beta)(AA306-332)

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  • 产品厂商：半导体
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简单介绍：
anti-SCNN1Bantibody(SodiumChannel,Nonvoltage-Gated1,beta)(AA306-332)
详情介绍：
Immunogen This SCNN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-332 amino acids from the Central region of human SCNN1B.
Clone RB42043
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name SCNN1B (SCNN1B Antibody Abstract)
Background Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.

Synonyms: SCNN1B, Amiloride-sensitive sodium channel subunit beta, Beta-NaCH, Epithelial Na(+) channel subunit beta, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB
NCBI Accession NP_000327
UniProt P51168
Research Area Cancer, Metabolism
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) (AA 306-332), (Center) antibody (ABIN1881778) SCNN1B Antibody (Center) (ABIN1881778) western blot analysis in ZR-75-1 cell line lys...
Product cited in: Song, Wei, Zhou, Lazrak, Liu, Londino, Squadrito, Matalon: "Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9716-28, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Azad, Rauh, Vermeulen, Jaspers, Korbmacher, Boissier, Bassinet, Fichou, des Georges, Stanke, De Boeck, Dupont, Balascáková, Hjelte, Lebecque: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, 2009 (PubMed).