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  • 产品名称：anti-IKBKBantibody(InhibitorofkappaLightPolypeptideGeneEnhancerinB-Cells,Kinase

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简单介绍：
anti-IKBKBantibody(InhibitorofkappaLightPolypeptideGeneEnhancerinB-Cells,Kinasebeta)(pSer701)
详情介绍：
Immunogen This mouse IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S701 of mouse IKKB.
Clone RB40105
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name IKKB (IKBKB Antibody Abstract)
Background NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

Synonyms: Ikbkb, Ikkb, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta
NCBI Accession NP_034676
UniProt O88351
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades
Application Notes DB: 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Dot Blot (DB) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (pSer701) antibody (ABIN1881452) Dot blot analysis of mouse IKKB Antibody (Phospho S701) Phospho-specific Pab (ABIN188...
Product cited in: Busuttil, Droin, McCormick, Bernassola, Candi, Melino, Green: "NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 42, pp. 18061-6, 2010 (PubMed).

Kenneth, Mudie, Rocha: "IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function." in: The EMBO journal, Vol. 29, Issue 17, pp. 2966-78, 2010 (PubMed).

Tsuchiya, Asano, Nakayama, Kato, Karin, Kamata: "Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation." in: Molecular cell, Vol. 39, Issue 4, pp. 570-82, 2010 (PubMed).

Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: "Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression." in: Immunity, Vol. 33, Issue 1, pp. 25-34, 2010 (PubMed).